Yes, you can create a new measure that is a calculation based on one or more other measures. There are two "types" of calculations available in Flow:
Use an Aggregated measure to aggregate a measure from a smaller time period (i.e. Hour) to a bigger time period (i.e. shift, day, week, month, etc.)
For example, if we have a measure that collects hourly production counts from a Tag Historian, we can then create another measure that sums the results of this hourly measure to create a value for the production day.
Use a Calculated measure to create a calculation from one or more other measures for the same time period.
For example, if we have an hourly measure for production counts, and an hourly measure for electricity used, we can create an hourly calculated measure for the ratio of electricity used per unit of production.
Calculations can be nested. Calculations can make use of built-in functions similar to functions you would find in Excel, or you can define your own User Defined Functions.